DNA methylation of food sensitization in a French-Canadian population.

ABSTRACT:

Background

Food allergy (FA) is a great public health concern with an increased prevalence in the last decades. The underlying development mechanisms of FA and food sensitization (FS), which represents the first stage of development of FA, are influenced by environmental, epigenetic, and genetic factors. DNA methylation is an important epigenetic mediator of gene-environment interactions and key to understanding these mechanisms. Studies have linked whole-genome DNA methylation profile to FA and FS, but they all use methylation arrays. Methylation sequencing captures target regions of methylome with an extensive coverage. Thus, our objective was to identify CpG sites in genome-wide immune regulatory regions associated with FS and test their association with genetic variants using m

SUBMITTER: Tremblay BL 

PROVIDER: S-EPMC12359973 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature