NSAID-Induced acute kidney injury risk in patients on renin-angiotensin system inhibitors and diuretics: nationwide cohort study.

ABSTRACT:

Background

Triple Whammy (TW) therapy, a combination of renin-angiotensin system inhibitors (RASIs), diuretics, and non-steroidal anti-inflammatory drugs (NSAIDs), is associated with an increased risk of acute kidney injury (AKI). However, there is no consensus regarding the impact of NSAID type on the risk of AKI. Therefore, in this study, we evaluated the incidence and risk of NSAID-induced AKI in patients taking concomitant RASIs and diuretics, focusing on NSAID type.

Methods

We conducted an observational retrospective cohort study using a Japanese medical claims database. In the cohort analysis, 41,904 patients who received concomitant RASIs, diuretics, and newly added NSAIDs between April 2020 and March 2021 were included to estimate AKI incidence. In the case-crossover

SUBMITTER: Kunitsu Y 

PROVIDER: S-EPMC12359997 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature