The epigenetics effects of transposable elements are genomic context dependent and not restricted to gene silencing in Drosophila.

ABSTRACT:

Background

Transposable elements (TEs) represent a threat to genome integrity due to their proliferative capacity. Eukaryotic cells silence TEs through different molecular mechanisms, including the deposition of repressive histone marks. Previous studies have shown that TE repressive marks can spread to neighboring sequences. However, evidence for this spreading leading to nearby gene silencing remains limited. Similarly, whether TEs induce changes in the enrichment of active histone marks genome-wide, and the potential impact on gene expression have not been widely studied.

Results

In this work, we perform a comprehensive study of the epigenetic effects of 2235 TEs and their potential effects on nearby gene expression on Drosophila melanogaster head, gut, and ovary. While m

SUBMITTER: Coronado-Zamora M 

PROVIDER: S-EPMC12360000 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature