Ferritin-armed extracellular vesicles with enhanced BBB penetration and tumor-targeting ability for synergistic therapy against glioblastoma.

ABSTRACT: Glioblastoma multiforme (GBM) is an aggressive brain cancer with a high mortality rate and limited treatment options. Metabolism-based synergistic therapy holds promise for GBM treatment, however, its efficacy is significantly impeded by poor blood-brain barrier (BBB) penetration, inadequate targeting of GBM cells, and systemic drug-related side effects. To address these challenges, we herein developed a dual-targeting nanoplatform, EVs@siMCT4-HFn@AuMn, by arming siMCT4-loaded M1-type microglia-derived extracellular vesicles (EVs) with ultrasmall nano-Au/MnO₂-loaded H-ferritin (HFn). This nanoplatform enhances tumor accumulation through cooperative BBB penetration and the GBM-targeting properties of EVs and HFn. Within the GBM microenvironment, siMCT4 silences MCT4 expression, i

SUBMITTER: Lu G 

PROVIDER: S-EPMC12360009 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature