Unveiling migraine subtype heterogeneity and risk loci: integrated genome-wide association study and single-cell transcriptomics discovery.

ABSTRACT:

Background

Migraine, a debilitating neurological disorder with distinct subtypes (migraine with aura [MA] and migraine without aura [MO]), exhibits genetic and spatial heterogeneity that remains poorly understood. While genetic correlations between subtypes are established, spatially resolved molecular mechanisms driving their divergent clinical phenotypes-particularly in tissue microenvironments-are unclear, limiting targeted therapeutic development.

Methods

We integrated genome-wide association study (GWAS) data from FinnGen R11 and international cohorts with transcriptomic, epigenomic, and spatially resolved single-cell spatial transcriptomics (sc-ST) profiles. Genetic correlations and functional annotations were assessed using Linkage Disequilibrium Score Regression (LDS

SUBMITTER: Wei S 

PROVIDER: S-EPMC12360011 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature