Can Twisted Double Bonds Facilitate Stepwise [2 + 2] Cycloadditions?

ABSTRACT: Computational studies for a series of low to high strain anti-Bredt alkenes suggest that those with highly twisted bridgehead double bonds and a small singlet-triplet energy gap may undergo facile stepwise [2 + 2] cycloadditions to furnish four membered rings. A selection of reaction substrates, including ethylene, acetylene, perfluoroethylene, and cyclooctyne are considered.

SUBMITTER: Viesser RV 

PROVIDER: S-EPMC12360032 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature