The landscape of long noncoding RNA during cutaneous squamous cell carcinoma progression.

ABSTRACT:

Background

Cutaneous squamous cell carcinoma (cSCC) is a common cancer with a high morbidity rate and poor prognosis for metastatic disease. Disease may progress from premalignant actinic keratosis to invasive and metastatic cSCC, but it is perhaps best characterized as a disease continuum progressing from a differentiated to a progenitor-like state. The critical molecular mediators of this process remain poorly defined. Long noncoding (lnc)RNAs, a relatively unexplored class of RNA molecules > 200 nucleotides long, are likely to have important functional roles in cSCC.

Objectives

To provide a comprehensive landscape of lncRNA expression during the cSCC continuum and to identify potentially functional lncRNA drivers of disease progression.

Methods

We interrogated bulk

SUBMITTER: Bone M 

PROVIDER: S-EPMC12360040 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature