Correlation of ⁶⁸Ga-RM2 PET with Postsurgery Histopathology Findings in Patients with Newly Diagnosed Intermediate- or High-Risk Prostate Cancer.

ABSTRACT: ⁶⁸Ga-RM2 targets gastrin-releasing peptide receptors (GRPRs), which are overexpressed in prostate cancer (PC). Here, we compared preoperative ⁶⁸Ga-RM2 PET to postsurgery histopathology in patients with newly diagnosed intermediate- or high-risk PC. Methods: Forty-one men, 64.0 ± 6.7 y old, were prospectively enrolled. PET images were acquired 42-72 min (median ± SD, 52.5 ± 6.5 min) after injection of 118.4-247.9 MBq (median ± SD, 138.0 ± 22.2 MBq) of ⁶⁸Ga-RM2. PET findings were compared with preoperative multiparametric MRI (mpMRI) (n = 36) and ⁶⁸Ga-PSMA11 PET (n = 17) and correlated to postprostatectomy whole-mount histopathology (n = 32) and time to biochemical recurrence. Nine participants decided to undergo radiati

SUBMITTER: Duan H 

PROVIDER: S-EPMC12360193 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature