UQCRC1 downregulation impairs cognitive function in mice <i>via</i> AMPK inactivation.

ABSTRACT:

Background

Ubiquinol-cytochrome c reductase core protein 1 (UQCRC1) is an essential subunit of complex III in the mitochondrial respiratory chain. Although earlier studies have indicated that UQCRC1 downregulation causes cognitive impairment, the underlying mechanisms remain unclear.

Methods

To investigate its pathophysiological effects, we developed a mouse model with downregulated UQCRC1 expression. Hippocampus-dependent cognitive performance was evaluated using a series of behavioral paradigms. Mitochondrial bioenergetic status was assessed by measuring adenosine triphosphate (ATP) levels, while oxidative stress was quantified through detection of reactive oxygen species (ROS). Molecular analyses were performed to assess AMP-activated protein kinase (AMPK) signaling dynam

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12360322 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature