Epidemiology and genetic characteristics of <i>Clostridioides difficile</i> isolates in Northwest China.

ABSTRACT: Clostridioides difficile (C. difficile) is a significant hospital-acquired pathogen that can cause antibiotic-associated diarrhea. In this study, we investigate the epidemiological and genetic characteristics of C. difficile isolates from a tertiary hospital in Northwest China. We prospectively collected fecal samples from 212 patients with diarrhea between January 2023 and May 2024 at the First Hospital of Lanzhou University. Twenty-five (11.8%, 25/212) strains of C. difficile were isolated, and twenty (9.4%, 20/212) were identified as toxigenic C. difficile (TCD). The dominant toxin gene profiles were tcdA+ B+ (80%, 20/25). Furthermore, twelve different sequence types (STs) belonging to three clades were identified, and the most prevalent types w

SUBMITTER: Li Y 

PROVIDER: S-EPMC12360323 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature