Novel hypnotics use and hip fracture risk in middle-aged and older adults: A large, population-based cohort study in Japan.

ABSTRACT:

Aim

To investigate the relationship between the prescription of novel hypnotics (melatonin receptor agonists [MRAs] and orexin receptor antagonists [ORAs]) and the risk of hip fractures in a large cohort of Japanese patients.

Methods

In this retrospective study, we analyzed data from a large health insurance claims database. Among subscribers aged ≥50 years between April 2014 and September 2021, those assigned the disease code of hip fracture were included. Each patient's prescription history for hypnotics was examined to identify the exposure and non-exposure periods. The relationship between exposure to hypnotics and the development of hip fractures was analyzed using the Mayo-updated Cox proportional hazards regression model.

Results

In total, 269,097 patients deve

SUBMITTER: Shibata N 

PROVIDER: S-EPMC12360458 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature