Critical roles of <i>Drosophila</i> ubiquitin carboxyl-terminal hydrolase in eye development.

ABSTRACT: Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a protein in the ubiquitin-proteasome system involved in numerous cellular processes and implicated in various human diseases, including cancer, neurodegenerative diseases, and metabolic syndrome. However, its roles in development remain poorly understood. In this study, we used Drosophila melanogaster as a model to investigate the function of UCH-L1. The Drosophila homolog of UCH-L1, Uch, was specifically knocked down in the eye imaginal disk using RNA interference (RNAi). The results showed that loss of Uch function induced a rough eye phenotype characterized by abnormal ommatidia, including disorganized arrangement, variable sizes, and irregular orientations. In addition, Uch knockdown significantly affected cone

SUBMITTER: Cao TTT 

PROVIDER: S-EPMC12360465 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature