IPaul^Het - spatially-defined, wingtip-flexible, N,C-chelating oxazole and thiazole donor N-heterocyclic carbene ligands.

ABSTRACT: N-Heterocyclic carbenes (NHCs) are among the most versatile ligands in transition metal catalysis with their steric and electronic properties playing a critical role in governing reactivity and selectivity. In this area, the wingtip unsymmetrical IPaul ligand introduced by Nelson and co-workers offers a unique balance of steric bulk and flexibility characterized by spatially-defined steric features. Herein, we report a new class of IPaul-based ligands bearing benzoxazole and benzothiazole donor wingtips. The synthesis, application, and structural and electronic characterization are described. These ligands retain the defining 'bulky yet flexible' profile of IPaul, while enabling precise control over the catalytic pocket geometry through N-heteroaryl wingtip substitution. We present their c

SUBMITTER: Podchorodecka P 

PROVIDER: S-EPMC12360485 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature