The role of SLC2A1 in lung adenocarcinoma: From tumorigenesis to patient survival.

ABSTRACT:

Objective

Our study aimed at systematically exploring the effect of the solute carrier family 2 Member (SLC2A) genes family on the prognosis and immune landscape of lung adenocarcinoma (LUAD) patients. Furthermore, we sought to determine the SLC2A1 function in LUAD initiation and progression through in vivo and in vitro experiments.

Methods

A comprehensive bioinformatics analysis was conducted utilizing online tools and software, including R packages, Gene Set Cancer Analysis (GSCA), cBio Cancer Genomics Portal (cBioPortal), GeneMANIA, STRING, and Xiantao Academic Online databases, to assess the functional implications of the SLC2A gene family in LUAD. Concurrently, in vivo and in vitro experiments at the cellular and animal levels were conducted to ascertain the effects of

SUBMITTER: Xiao Z 

PROVIDER: S-EPMC12360529 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature