Cysteine dioxygenase knockout and taurine deficiency impair mouse uterine adenogenesis by inhibiting epithelial cell proliferation and enhancing apoptosis.

ABSTRACT: Uterine glands and their secretions are essential for conceptus survival and development, with abnormalities in uterine gland morphogenesis (adenogenesis) are closely related to high rates of peri-implantation embryonic loss in humans and livestock. While uterine adenogenesis occurs postnatally in most mammals, the key regulatory factors and mechanisms governing this developmental event remains largely unexplored. Our recent study reveals that cysteine dioxygenase (CDO) is highly expressed in the uterus of adult mice, which is also rich in taurine. Notably, Cdo knockout (KO) and the resulting taurine deficiency lead to the defects in embryo implantation and subfertility. However, the regulatory roles of CDO and taurine in uterine development and adenogenesis remain unclear. In the current

SUBMITTER: Liu H 

PROVIDER: S-EPMC12360574 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature