Investigation of mobile genetic elements and their association with antibiotic resistance genes in clinical pathogens worldwide.

ABSTRACT:

Objectives

Antimicrobial-resistant bacteria are a major global health threat. Mobile genetic elements (MGEs) have been crucial for spreading resistance to new bacterial species, including human pathogens. Understanding how MGEs promote resistance could be essential for prevention. Here we present an investigation of MGEs and their association with resistance genes in pathogenic bacteria collected from 59 diagnostic units during 2020, representing a snapshot of clinical infections from 35 counties worldwide.

Methods

We analysed 3,095 whole-genome sequenced clinical bacterial isolates from over 100 species to study the relationship between resistance genes and MGEs. The mobiliome of Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Klebsiella pneumoniae were

SUBMITTER: Johansson MHK 

PROVIDER: S-EPMC12360581 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature