Long-term clinical sequelae in severe fever with thrombocytopenia syndrome: A longitudinal cohort study.

ABSTRACT:

Background

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease characterized by a high case fatality rate. Despite extensive research on acute-phase manifestations, the long-term clinical sequelae in survivors remain poorly characterized.

Methods

In this prospective cohort study from 2010 to 2024, 1,197 SFTS survivors and 188 age/sex-matched febrile controls without SFTS were enrolled from the highest endemic region in China. Participants underwent face-to-face interview, serial clinical evaluations and laboratory testing at 6, 12, 18 and 24 months post-discharge, with extended follow-up for a subset (n = 294) over 11 years. Propensity score matching and multivariate logistic regression were used to determine the factors associated

SUBMITTER: Cui N 

PROVIDER: S-EPMC12360653 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature