Deep brain stimulation modulates directional limbic connectivity in major depressive disorder.

ABSTRACT:

Background

Deep brain stimulation (DBS) is being investigated as a treatment for patients with refractory major depressive disorder (MDD). However, little is known about how DBS exerts its antidepressive effects. Here, we investigated whether ventral anterior limb of the internal capsule stimulation modulates a limbic network centered around the amygdala in patients with treatment-resistant MDD.

Methods

Nine patients underwent resting state functional magnetic resonance scans before DBS surgery and after 1 year of treatment. In addition, they were scanned twice within 2 weeks during the subsequent double-blind cross-over phase with active and sham treatment. Twelve matched controls underwent scans at the same time intervals to account for test-retest effects. The imaging dat

SUBMITTER: Fridgeirsson EA 

PROVIDER: S-EPMC12360689 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature