Diazepam modulates hippocampal CA1 functional connectivity in people at clinical high-risk for psychosis.

ABSTRACT:

Background

Preclinical evidence suggests that diazepam enhances hippocampal γ-aminobutyric acid (GABA) signalling and normalises a psychosis-relevant cortico-limbic-striatal circuit. Hippocampal network dysconnectivity, particularly from the CA1 subfield, is evident in people at clinical high-risk for psychosis (CHR-P), representing a potential treatment target. This study aimed to forward-translate this preclinical evidence.

Methods

In this randomised, double-blind, placebo-controlled study, 18 CHR-P individuals underwent resting-state functional magnetic resonance imaging twice, once following a 5 mg dose of diazepam and once following a placebo. They were compared to 20 healthy controls (HC) who did not receive diazepam/placebo. Functional connectivity (FC) between the hi

SUBMITTER: Livingston NR 

PROVIDER: S-EPMC12360692 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature