Neurofunctional representations of instrumental learning in psychosis: a meta-analysis of neuroimaging studies.

ABSTRACT:

Background

Establishing appropriate action-outcome associations can allow animals and humans to control behavior and the environment in a goal-directed manner. Deficits in instrumental learning in psychosis have been widely reported in past studies, but the results remain elusive.

Study design

To explore the consistent neural representations of instrumental learning in functional magnetic resonance imaging (fMRI) in individuals with psychosis, a total of 18 studies (458 individuals with psychosis and 454 controls) were included in our coordinate-based meta-analysis.

Study results

Patients with psychosis presented increased activation in the left middle occipital gyrus, insula, and lingual and postcentral gyri; decreased activation in cortico-striato-thalamo-cortical (

SUBMITTER: Song Y 

PROVIDER: S-EPMC12360695 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature