Zwitterionic alginate derivative as a new delivery platform for enhanced blood circulation.

ABSTRACT:

Purpose

Poly(ethylene glycol) (PEG), a synthetic polymer known for its hydrophilicity and biocompatibility, has long been used in drug delivery systems to prevent non-specific protein adsorption and to extend the blood circulation time of drug carriers and protein drugs. However, PEG has several drawbacks including poor stability, accumulated toxicity, and immunogenicity induced by repeated injections. Recently, zwitterionic polymers, known for their super-hydrophilic and antifouling properties, have been considered excellent alternatives to PEG. In this study, we synthesized a new zwitterionic polymer from biocompatible sodium alginate and lysine.

Methods

Sodium alginate (Alg) was conjugated with lysine (Lys) using the EDC/sulfo-NHS chemistry to form a zwitterionic alginate

SUBMITTER: Lee H 

PROVIDER: S-EPMC12360706 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature