Genotype Distribution and Migration Patterns of Hepatitis C Virus in Shandong Province, China: Molecular Epidemiology and Phylogenetic Study.

ABSTRACT:

Background

Hepatitis C virus (HCV) remains a significant public health concern in China, particularly in Shandong Province, where detailed molecular epidemiological data are limited. HCV exhibits substantial genetic diversity, and understanding its genotype distribution and transmission dynamics is critical for developing effective control strategies.

Objective

This study aimed to investigate the genetic diversity, geographic dissemination, and evolutionary history of HCV genotypes in Shandong Province, China, using molecular techniques and phylogenetic methods.

Methods

A total of 320 HCV-positive serum samples were collected from multiple hospitals across Shandong Province between 2013 and 2021. HCV RNA was extracted and amplified targeting the 5' untranslated region

SUBMITTER: Lin L 

PROVIDER: S-EPMC12360734 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature