Gut metagenomes reveal interactions between dietary restriction, ageing and the microbiome in genetically diverse mice.

ABSTRACT: The gut microbiome changes with age and has been proposed to mediate the benefit of lifespan-extending interventions such as dietary restriction. However, the causes and consequences of microbiome ageing and the potential of such interventions remain unclear. Here we analysed 2,997 metagenomes collected longitudinally from 913 deeply phenotyped, genetically diverse mice to investigate interactions between the microbiome, ageing, dietary restriction (caloric restriction and fasting), host genetics and a range of health parameters. Among the numerous age-associated microbiome changes that we find in this cohort, increased microbiome uniqueness is the most consistent parameter across a second longitudinal mouse experiment that we performed on inbred mice and a compendium of 4,101 human metage

SUBMITTER: Litichevskiy L 

PROVIDER: S-EPMC12360852 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature