Fractionated Gamma Knife Radiosurgery as a Primary Treatment for Large Brain Metastases.

ABSTRACT:

Background

To assess the effectiveness of fractionated Gamma Knife radiosurgery (fGKS) as a primary treatment for newly diagnosed large (> 10 cm³) brain metastases.

Methods

Ninety-three patients with newly diagnosed large brain metastases, comprising 99 lesions, who underwent fGKS were included in this retrospective study. Tumor and edema volumes were measured using follow-up magnetic resonance imaging for longitudinal analysis. Local or distant progression-free survival (PFS) rate in the brain, and overall survival (OS) rates were analyzed. Cox regression analysis was used to assess prognostic factors for local progression. Radiation toxicity was evaluated based on RTOG CNS toxicity grades.

Results

Median local PFS was 15.5 months, distant PFS was 13.2 months, overal

SUBMITTER: Myeong HS 

PROVIDER: S-EPMC12360905 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature