Association between vitamin B6 status and liver fibrosis: evidence from NHANES 2005-2010.

ABSTRACT: Liver fibrosis (LF) is a chronic liver disease with an increasing global prevalence, caused by various underlying factors. Vitamin B6 is significantly altered during inflammation and has been associated with diabetes and hypertension. To date, no study has explored the association between vitamin B6 and LF. We aimed to explore the association between vitamin B6 metabolites-4-pyridoxine acid (4-PA), pyridoxal 5'-phosphate (PLP), and the 4-PA/PLP ratio (an indicator of vitamin B6 metabolism rate in the body)-and LF risk. Data were extracted from the National Health and Nutrition Examination Surveys 2005-2010. Serum levels of 4-PA, PLP, and the 4-PA/PLP ratio were used to assess vitamin B6 status. The LF score was used to assess LF. Univariate and multivariate logistic regression tests were p

SUBMITTER: Peng J 

PROVIDER: S-EPMC12360946 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature