Mining and evaluation of security alert signals of neuroprotective agents based on the Jinan adverse event reporting system database: a retrospective study.

ABSTRACT: Pharmacologic agents with proposed neuroprotective properties are increasingly investigated; however, limited regulation and heterogeneous evidence raise concerns about their safety profiles. To establish a foundation for its safe clinical use, the data mining technology was used to investigate the safety warning signals of neuroprotective agent post-market approval. The Jinan adverse event (AE) reporting system database was searched for AEs related to neuroprotective agents from January 2000 to March 2022. Basic information pertaining to patients, reports, and common AEs was analyzed. Subgroup analyses were performed to examine the distribution of adverse reaction signals for each drug across different age groups and genders. Sensitivity analyses were conducted by stratifying patients bas

SUBMITTER: Guan YY 

PROVIDER: S-EPMC12361204 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature