Cartilage thickness distribution and its dependence on demographic, radiographic, and MRI structural pathology in knee osteoarthritis-data from the IMI-APPROACH cohort.

ABSTRACT:

Objective

Cartilage surface mapping is a technique that can visualize 3D cartilage thickness variation throughout a joint without a need for arbitrary regional definitions. The objective of this cross-sectional study was to utilize this technique to evaluate the cartilage thickness distribution in knee osteoarthritis patients and to analyze to what extent it depends on demographic, radiographic, and MRI structural pathology strata.

Methods

Patients of the IMI-APPROACH cohort were included, with MRIs obtained at 1.5 T or 3 T. Tibial and femoral cartilage segmentation and registration with a canonical surface were performed semi-automatically. Kellgren-Lawrence and OARSI grading were performed on knee radiographs; MOAKS scoring was performed on MRI scans. The association of de

SUBMITTER: Jansen MP 

PROVIDER: S-EPMC12361290 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature