Expression and Regulatory Roles of SKAP2 and Cortactin in Mouse Ovarian Tissue and Oocyte Maturation.

ABSTRACT: Oocyte maturation is a critical phase in mammalian reproduction. Src kinase-associated phosphoprotein 2 (SKAP2) and cortactin, both cytoskeletal regulatory proteins that play pivotal roles in cell motility and signal transduction. However, their specific functions and mechanisms during oocyte maturation are currently unknown. This study revealed the roles of SKAP2 and cortactin in the oocyte maturation process. To investigate the distribution, activity, and functional significance of SKAP2 during murine oocyte asymmetric division, ovarian tissues were infected with lentiviruses expressing SKAP2 and cortactin shRNA. Cell morphology was analyzed to assess the expression and distribution of cyclins, SKAP2, Wiskott-Aldrich syndrome protein family member 2 (WAVE2), and cortactin. Additionally,

SUBMITTER: Feng Y 

PROVIDER: S-EPMC12361339 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature