Prenatal maternal HFD exposure impairs cognition via a hippocampal NMDA mechanism.

ABSTRACT: Maternal obesity increases the risk of neurodevelopmental disorders and cognitive impairments in offspring later in life. Most animal studies investigated the effects of maternal high-fat diet (HFD) from pre-mating to lactation on offspring neurodevelopment and cognitive function. However, the specific impact of in-utero exposure to maternal HFD on the cognitive function in offspring remains limited. In this study, female dams were fed laboratory chow or HFD for 11 weeks: 8 weeks before conception and during gestation. To isolate the prenatal effects, newborns were reared by foster mothers under control-diet conditions during lactation. Behavioral tests were conducted between postnatal days 42 and 56. Our results demonstrate that maternal HFD exposure in utero impaired spatial working memo

SUBMITTER: Chen KR 

PROVIDER: S-EPMC12361442 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature