A self-powered hydration-monitoring and drug-delivery skin patch for closed-loop treatment of atopic dermatitis.

ABSTRACT: Atopic dermatitis is a chronic inflammatory skin condition that typically manifests in infancy and is characterized by dry, irritated skin. Here, we propose a self-powered hydration-monitoring and drug-delivery skin patch for closed-loop treatment of atopic dermatitis. The patch is composed of piezoelectric generator, hydration sensing unit, microneedle treatment module and flexible circuit. The piezoelectric PZT generator can achieve self-powering by harvesting mechanical energy from patient activities, allowing for long-term work of the system without external power sources. The hydration sensing unit can rapidly and accurately detect changes in skin hydration by estimating the thermal conductivity. Upon detecting abnormal skin hydration levels for 65 s, the treatment module is automatic

SUBMITTER: Liang S 

PROVIDER: S-EPMC12361490 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature