Temperature-dependent modulation of light-induced circadian responses in Drosophila melanogaster.

ABSTRACT: Animals entrain their circadian rhythms to multiple external signals, such as light and temperature, which are integrated in master clock neurons to adjust circadian phases. However, the precise mechanisms underlying this process remain unclear. Here, we use in vivo two-photon calcium imaging while precisely controlling temperature to investigate how the Drosophila melanogaster circadian clock integrates light and temperature inputs in circadian neurons. We show that light responses modulate the circadian clock in central pacemaker neurons, with temperature acting as a fine-tuning mechanism to achieve optimal adaptation. Our results suggest that temperature-sensitive dorsal clock neurons DN1as regulate the light-induced firing of s-LNv circadian pacemaker neurons and release of the neurope

SUBMITTER: Tian Y 

PROVIDER: S-EPMC12361518 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature