Restoring mucosal barrier homeostasis by in situ formation of a living-synthetic therapeutic coating.

ABSTRACT: The mucosal barrier consisting of physicochemical, immune, and microbial components is the first line of defense against external stimuli. Breakdown of the mucosal barrier causes the occurrences of various diseases, while methods capable of multifacetedly restoring mucosal barrier functions have been rarely reported. Here, we describe the restoration of the physicochemical, immune, and microbial homeostasis of the mucosal barrier by in situ formation of a living-synthetic therapeutic coating (LSTC). Through metal-phenolic complexation and π-π stacking interactions, ethyl gallate can chelate Bi^III ions to form an adhesive coating on mucosal surfaces, which enables further hybridization with living bacteria. Due to the beneficial effects of Bi^III and ethyl gallate and t

SUBMITTER: Yu W 

PROVIDER: S-EPMC12361522 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature