Ziziphus spina-christi alleviates paracetamol-induced hepatorenal toxicity in rats through in vivo and computational approaches.

ABSTRACT: Paracetamol (PCM) overdose is a leading cause of drug-induced liver and kidney injury, necessitating effective therapeutic strategies. This study aimed to evaluate the protective effects of Ziziphus spina-christi (ZSC), a traditional medicinal plant with documented antioxidant and protective properties against PCM-induced hepatorenal toxicity in rats, integrating both in vivo and computational approaches. Male rats were divided into four groups: control (vehicle), PCM (300 mg/kg), ZSC (400 mg/kg), and PCM + ZSC (combined treatment). Treatments were administered daily for 14 days. The study included biochemical analysis of liver and kidney function markers, oxidative stress indicators, histological and immunohistochemical examinations, and molecular docking studies. Statistical significance

SUBMITTER: Khedre EKM 

PROVIDER: S-EPMC12361524 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature