Polymer-free β-cyclodextrins and mefenamic acid inclusion complex nanofibers for enhanced drug solubility and biomedical applications.

ABSTRACT: In this study, cyclodextrin (CDs) derivatives were used to form mefenamic acid (MFA) supramolecular inclusion complexes (ICs) via a polymer-free electrospinning technique, aiming to improve drug delivery and therapeutic applications. MFA, a non-steroidal anti-inflammatory drug (NSAID), has low water solubility, but its solubility increases when complexed with CDs. Three β-CDs derivatives such as hydroxypropyl β-cyclodextrins (HCN), methyl β-cyclodextrins (MCN), and sulfobutylether β-cyclodextrins (SCN) were used for MFA ICs. Phase solubility studies showed increased MFA solubility with rising amounts of CDs, with stability constants of 337.1, 684.2, and 931.5 M^- 1 for β-CDs: MFA (HCN: MFA, MCN: MFA, and SCN: MFA). SEM analysis of electrospun β-CDs: MFA nanofibers revealed bead-f

SUBMITTER: Mohandoss S 

PROVIDER: S-EPMC12361529 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature