Modelling transmission of Middle East respiratory syndrome coronavirus in camel populations and the potential impact of animal vaccination.

ABSTRACT: Outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) in humans are driven by recurring zoonotic spillover from camels, leading to demand for camel vaccination. With two vaccine candidates shown to reduce infectiousness, there is a need to better understand transmission of MERS-CoV in camels and assess the potential impact of vaccination. To help address this, we used age-stratified seroprevalence data and a combination of modelling methodologies to estimate key epidemiological quantities including MERS-CoV transmissibility in camels and to estimate vaccine impact on infection incidence. Transmissibility was higher in West Asia (R₀ interquartile range 7-14) compared to Africa (3-5) and South Asia (2-3), highlighting the need for setting-specific vaccination strate

SUBMITTER: Dighe A 

PROVIDER: S-EPMC12361541 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature