Proteogenomic characterization of invasive breast tumors in young women.

ABSTRACT: Breast cancer in women <40, accounting for ~5% of all breast cancer cases diagnosed in the U.S., is more aggressive and associated with worse outcomes compared to breast cancer in older women. We performed a first-ever integrated proteogenomic study from a matched cohort of laser-microdissected tumors of 34 young (<40 years) and 34 older (≥60 years) women to identify molecular features that may underlie the worse outcomes in young women. Progression-free interval was shorter in young women, and their tumors were enriched for more aggressive molecular subtypes. Our multi-omic analysis identified distinct clusters between age groups in luminal but not basal-like cancers. Notably, GATA3 mutations were enriched in luminal tumors from young women while TP53 and PIK3CA mutations were more common

SUBMITTER: Raj-Kumar PK 

PROVIDER: S-EPMC12361583 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature