Obesity-related brain atrophy is independent of Alzheimer's disease protein pathways.

ABSTRACT: BackgroundObesity increases the risk for Alzheimer's disease (AD) and other dementias. Obesity causes structural brain injury, and it has been suggested that this may contribute to the development of AD pathology. Neurodegeneration in AD results from the aggregation of misfolded and dysfunctional tau and amyloid-β. However, it remains unknown whether adiposity-related brain injury acts through tau and amyloid deposition or as an independent cause of neurodegeneration.ObjectiveHere, we tested whether obesity, cerebrovascular disease, and obesity-related metabolic risk score were associated with structural brain and cognitive changes via the same mechanisms as AD or independent of them.MethodsWe used the UK Biobank sample of over 33,000 individuals aged 64 years on average. We tested the inf

SUBMITTER: Morys F 

PROVIDER: S-EPMC12361701 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature