Outcomes Associated with Time in Therapeutic Range for Patients Receiving Intravenous Unfractionated Heparin.

ABSTRACT: Time in therapeutic range (TTR) with intravenous unfractionated heparin (UFH) and its association with outcomes is poorly explored. UFH can be monitored with anti-Xa or aPTT, however, evidence indicates anti-Xa monitoring of UFH improves time to therapeutic anticoagulation. The objective of this study was to determine if TTR correlates with thrombotic and safety outcomes for patients receiving UFH, and if differences exist between these methods of monitoring. This retrospective, single center, cohort study stratified patient admissions based on the laboratory monitoring technique used (aPTT vs anti-Xa). The primary outcome was the presence of a new thrombotic event (TE) during the index visit. The secondary outcome was major bleeding during the index visit. Clinical outcomes were each asse

SUBMITTER: Mahmud M 

PROVIDER: S-EPMC12361720 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature