Integrative evaluation of shear wave elastography and renal function biomarkers for predicting renal fibrosis in chronic kidney disease patients.

ABSTRACT: ObjectiveWe hypothesize that combining point shear wave elastography (PSWE) with clinical risk factors enables accurate renal fibrosis assessment. This retrospective study integrates PSWE with serum creatinine (Scr) and estimated glomerular filtration rate (eGFR) to develop and validate a nomogram for personalized renal fibrosis evaluation in chronic kidney disease (CKD) patients.MethodsA total of 157 patients underwent renal PSWE and kidney biopsy. PSWE measured cortical stiffness in the mid-portion of the right kidney. Feature importance was selected using elastic net regression, XGBoost, and random forest, with PSWE, Scr, and eGFR identified as key variables. Three models were established: Model 1 (PSWE + Scr + eGFR), Model 2 (Scr + eGFR), and Model 3 (PSWE). Diagnostic performance was

SUBMITTER: Wang J 

PROVIDER: S-EPMC12361741 | biostudies-literature | 2025 Jul-Sep

REPOSITORIES: biostudies-literature