MiR-363-5p regulates liver disease via the MAPK/ERK signaling pathway by targeting CPEB2 in chicken.

ABSTRACT: The liver is vital for laying hens, metabolizing nutrients, detoxifying, producing bile for digestion, regulating energy, and synthesizing yolk precursors, directly impacting egg production and health. MicroRNAs (MiRNAs) serve as central hepatic regulators, particularly influencing egg-laying efficiency through metabolic pathway control, detoxification modulation, and vitellogenesis. While miR-363-5p is implicated in liver metabolism and development across species, its specific roles in avian hepatic function remain underexplored. This study demonstrated that miR-363-5p induces lipogenesis, oxidative stress, and inflammation in chicken hepatocytes. Additionally, this study defined the interaction mechanism between miR-363-5p and its target genes and verified the cytoplasmic-polyadenylation

SUBMITTER: Xiang J 

PROVIDER: S-EPMC12361768 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature