Broader functionality of language areas at the left middle frontal gyrus in patients with Broca's area tumors.

ABSTRACT: The frontal language area (FLA; left posterior inferior frontal gyrus [pIFG] or Broca's area), critical for language processing can reorganize in response to lesion progression. While reorganization in the contralateral hemisphere is well known, how reorganization occurs within the ipsilateral hemisphere, especially in the perilesional region, remains unclear. Direct electrical stimulation (DES) during awake surgery enables identification of causal relationships between brain regions and language functions with high spatial resolution. In this study, we investigated cortical reorganization within the ipsilateral hemisphere of the FLA. Seventy-two patients with left hemisphere gliomas were studied. Patients were divided into FLA and non-FLA groups based on whether lesions included the pIFG

SUBMITTER: Nakajima R 

PROVIDER: S-EPMC12361790 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature