¹⁸F-FDG PET in detection of primary age-related tauopathy (PART) - Is there a role? Insights from an imaging-pathology correlation study.

ABSTRACT:

Introduction

Primary age-related tauopathy (PART) is defined by neurofibrillary tangles (NFTs) with absent-minimal amyloid beta (Aβ) plaques. Currently, definitive diagnosis of PART occurs with autopsy. This study investigated whether [¹⁸F]fluorodeoxyglucose positron emission tomography (FDG-PET) could detect PART-related metabolic changes and assessed the impact of common co-pathologies.

Methods

We performed a retrospective cross-sectional study of 88 individuals (mean age 85.6) with autopsy-confirmed PART (Braak I to IV; Thal phases 0 to 2) who underwent ante mortem FDG-PET. Visual ratings and standardized uptake value ratios (SUVRs) were analyzed in medial and lateral temporal lobes, inferior temporal pole, precuneus, and posterior cingulate regions.

Results

SUBMITTER: Lavrova A 

PROVIDER: S-EPMC12361867 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature