<i>CPA1</i> ^<i>S282P</i> mutation leads to chronic pancreatitis in rabbits.

ABSTRACT: Chronic pancreatitis (CP) is a progressive and irreversible fibroinflammatory disease that markedly increases susceptibility to pancreatic cancer and remains without effective targeted therapies. Among the genetic contributors to CP, the carboxypeptidase A1 p.Ser282Pro ( CPA1 ^S282P ) variant has been proposed to promote disease through misfolding-induced endoplasmic reticulum stress (ERS), although the broader pathogenic landscape remains incompletely defined. This study generated a rabbit model mimicking the human CPA1 ^S282P mutation using the SpRY-ABE-8.17 system. Homozygous CPA1 ^S282P rabbits exhibited characteristic human CP phenotypes following alcohol induction, including visceral pain, elevated serum lipase a

SUBMITTER: Yang J 

PROVIDER: S-EPMC12361900 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature