CCDC86-BHLHE40-ATF3 axis promotes aerobic glycolysis and tumor development in glioma.

ABSTRACT: Glioma, an aggressively malignant brain tumor with a poor prognosis, comprises nearly 50% of all primary malignant brain tumors. Despite its significance in other cancers, the role of coiled-coil domain containing 86(CCDC86) in glioma remains largely unexplored. Our study revealed a significant up-regulation of CCDC86 expression in glioma tissues, correlating notably with patient age, tumor recurrence, and pathological grade. Moreover, elevated CCDC86 level was associated with a worsened prognosis among glioma patients. Functional assays demonstrated that CCDC86 knockdown attenuated glioma cell proliferation and migration while inducing apoptosis and cell cycle arrest in vitro and inhibited tumorigenesis in vivo. Furthermore, ATF3 emerged as a downstream target gene of CCDC86

SUBMITTER: Liu J 

PROVIDER: S-EPMC12361992 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature