Cord red blood cell transfusions for severe retinopathy in preterm neonates in Italy: a multicenter randomized controlled trial.

ABSTRACT:

Background

Red blood cell (RBC) transfusions in preterm neonates are associated with retinopathy of prematurity (ROP).

Methods

BORN is a multicenter randomized trial investigating whether RBC transfusions from cord blood (CB-RBCs) instead of adult donors (A-RBCs) reduce ROP severity (NCT05100212). The study was conducted between December 2021 and November 2024 in 8 hospitals sited in 8 different Italian regions. Extremely low gestational age neonates (ELGANs) were randomized 1:1 to receive A-RBCs (control) or CB-RBCs (intervention) from birth to postmenstrual age (PMA) of 29 + 6 weeks. The main outcome was severe-ROP rate at 40 weeks PMA or discharge.

Findings

By intention-to-treat-analysis, 56 patients per arm were evaluated: 16 in the control arm and 14 in the inter

SUBMITTER: Teofili L 

PROVIDER: S-EPMC12361995 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature