Radiation dose escalation in locally advanced oesophageal cancer: a systematic review and hierarchical Bayesian meta-analysis.

ABSTRACT:

Background

The impact of radiation dose escalation in locally advanced oesophageal cancer remains controversial. While higher doses may improve locoregional control, their effect on overall survival (OS) and progression-free survival (PFS) remains uncertain. The aim of this study was to thoroughly evaluate the impact of dose escalation on survival.

Methods

A systematic search on Jan 4, 2025, identified studies evaluating definitive chemoradiotherapy (CRTx) for locally advanced oesophageal cancer stratified by radiation dose. Bayesian and frequentist meta-analyses assessed OS, PFS, and locoregional PFS (LRPFS). Meta-regression examined the influence of histology, tumour location, chemotherapy, and radiation techniques. Additional analyses included gene set enrichment analysis

SUBMITTER: Dai YH 

PROVIDER: S-EPMC12362008 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature