Phenotypic patterns of metabolic dysfunction-associated steatotic liver disease in type 2 diabetes: The impact of insulin.

ABSTRACT:

Background

Metabolic dysfunction-associated steatotic liver disease (MASLD) often leads to hepatic insulin resistance (IR), yet its link to liver-specific insulin-mediated glucose uptake (IGLU) in type 2 diabetes (T2D) remains unclear. We aimed to explore this MASLD-T2D relationship, addressing organ-specific IR for personalized management and risk prevention.

Methods

This cross-sectional study included 41 T2D participants enrolled in a clinical trial (NCT02248311) undergoing biochemical analyses, anthropometric measurements and [¹⁸F]FDG-PET/CT imaging before and after hyperinsulinemic euglycemic clamp (HEC).

Findings

Two MASLD-T2D phenotypes were identified according to their IGLU patterns, that is, with low (HepGluc[+], n = 21) and with high (HepGluc[-],

SUBMITTER: Martin-Saladich Q 

PROVIDER: S-EPMC12362049 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature