Contributions, bias, and research gaps in large animal ex vivo lung perfusion models: A systematic review.

ABSTRACT: A major challenge in lung transplantation is the shortage of viable donor lungs. Ex vivo lung perfusion (EVLP) has emerged as an effective assessment and conditioning tool to expand the donor lung pool. This systematic review sought to establish the contribution of large animal models to EVLP development and application, particularly focusing on assessing the risk of bias and the certainty of evidence. A strategic literature search was conducted using a predefined pro forma. Relevant data were extracted, and thematic analysis was applied for qualitative synthesis of key measures. Methodological quality and bias risk were assessed using systematic review centre for laboratory animal experimentation's risk of bias tool, and certainty of evidence was evaluated using the grading of recommendat

SUBMITTER: Fisher S 

PROVIDER: S-EPMC12362082 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature