Exploring proposed recommendations for immediate-use seizure medication: Treating both cluster and prolonged seizures with diazepam nasal spray.

ABSTRACT: The Seizure Termination Project developed expert consensus recommendations for outpatient management of seizure clusters and prolonged seizures to prevent progression to a higher-level emergency. The consensus recommendations described therapeutic scenarios for seizure clusters (acute cluster treatment [ACT]) to prevent further seizures in a cluster and treatment to stop ongoing seizures that were expected to be prolonged (rapid and early seizure termination [REST]). Here, we review ACT and REST as categories and explore their practical application by examining patient-level data for diazepam nasal spray. ACT and REST criteria were examined using data from the long-term safety study that evaluated diazepam nasal spray for seizure clusters. To explore the effectiveness and duration of treat

SUBMITTER: Chez M 

PROVIDER: S-EPMC12362174 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature