Comparative Efficacy and Safety of Different Tenecteplase Doses With Alteplase in Acute Ischemic Stroke: A Systematic Review With Pairwise and Network Meta-Analysis to Determine the Optimal Dose.

ABSTRACT:

Background

Tenecteplase (TNK) is a novel thrombolytic agent gaining attention as an alternative to alteplase for treating acute ischemic stroke (AIS). This meta-analysis evaluates the safety and efficacy of various TNK doses compared to alteplase, integrating recent randomized controlled trials (RCTs) and employing a frequentist network meta-analysis to identify the optimal dose while addressing existing evidence gaps.

Methods

Up until December 2024, PubMed, Cochrane Central, and ScienceDirect were searched. Using Review Manager 5.4.1 for pairwise meta-analysis, the Risk Ratios (RR) with 95% Confidence Intervals (CI) were pooled under the random effects model. Additionally, R version 4.3.2 and the "netmeta" package were used to conduct a network meta-analysis for various dos

SUBMITTER: Waseem MH 

PROVIDER: S-EPMC12362178 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature